Sendurai A. Mani is an Associate Professor in the Department of Translational Molecular Pathology at MD Anderson Cancer Center. Dr. Mani is also the co-director of the Metastasis Research Center as well as the Center for Stem Cell and Developmental Biology at MD Anderson Cancer Center. Dr. Mani’s laboratory uses various model systems, including cell lines, patient-derived tumor xenografts as well as mouse models to study the role of cancer stem cells (CSCs) in tumor progression. Dr. Mani’s original finding demonstrating the cancer cells acquire stem cell properties by activating latent embryonic epithelial-mesenchymal transition (EMT) program provided the foundation and explanation for the presence of plasticity within the tumor as well as the development of resistance to various treatments. This key finding also opened up doors for different biotech companies to target EMT signaling pathways to inhibit metastasis and therapy resistance by targeting EMT mediated tumor plasticity.
Dr. Mani earned a Ph.D. from Indian Institute of Science, Bangalore, India, and he did postdoctoral work with Dr. Robert A. Weinberg at the Whitehead Institute/Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. He then joined the University of Texas MD Anderson Cancer Center, Houston, Texas as an Assistant Professor and he is now an Associate Professor.